› 3ky2

X-ray diffraction
2.7Å resolution

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

Released:
DOI: 10.2210/pdb3ky2/pdb
PDB entry 3ky2 coloured by chain, front view.
PDB entry 3ky2 coloured by chain, side view.
PDB entry 3ky2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Bae JH, Boggon TJ, Tomé F, Mandiyan V, Lax I, Schlessinger J
Proc Natl Acad Sci U S A 107 2866-71 (2010)
PMID: 20133753

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 211.973Å b: 49.821Å c: 66.529Å
α: 90° β: 107.49° γ: 90°
R-values:
R R work R free
0.206 0.203 0.252
Expression system: Escherichia coli

Quick links

Citations

13 review citations

A structural perspective on the regulation of the epidermal growth factor receptor.
Kovacs et al. (2015)
12 more

13 mentions without citation

Pondering the mechanism of receptor tyrosine kinase activation: The case for ligand-specific dimer microstate ensembles.
Karl et al. (2021)
12 more