› 3kbz

X-ray diffraction
2.45Å resolution

Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6

Released:
DOI: 10.2210/pdb3kbz/pdb
PDB entry 3kbz coloured by chain, front view.
PDB entry 3kbz coloured by chain, side view.
PDB entry 3kbz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.
Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T
Bioorg Med Chem Lett 20 1004-7 (2010)
PMID: 20045638

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-1,6-bisphosphatase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 337 amino acids
Theoretical weight: 36.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09467 (Residues: 2-338; Coverage: 100%)
Gene names: FBP, FBP1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 2T4 4 x 2T4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 67.386Å b: 83.29Å c: 277.961Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.275
Expression system: Escherichia coli

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Citations

11 citation in other articles

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1 mention without citation

CARDIO-PRED: an in silico tool for predicting cardiovascular-disorder associated proteins.
Jain et al. (2015)