› 3jaf

Electron Microscopy
3.8Å resolution

Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state

Released:
DOI: 10.2210/pdb3jaf/pdb
PDB entry 3jaf coloured by chain, front view.
PDB entry 3jaf coloured by chain, side view.
PDB entry 3jaf coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Glycine receptor mechanism elucidated by electron cryo-microscopy.
Du J, Lü W, Wu S, Cheng Y, Gouaux E
Nature 526 224-9 (2015)
PMID: 26344198
Related structures: EMD-6346

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycine receptor subunit alphaZ1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 342 amino acids
Theoretical weight: 39.22 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O93430 (Residues: 34-436; Coverage: 81%)
Gene name: glra1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand IVM 5 x IVM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.801Å
Relevant EMDB volumes: EMD-6346
Expression system: Spodoptera frugiperda

Quick links

Citations

41 review citations

Unravelling biological macromolecules with cryo-electron microscopy.
Fernandez-Leiro et al. (2016)
40 more

29 mentions without citation

Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.
Giastas et al. (2018)
28 more