› 3j8w

Electron Microscopy
13Å resolution

Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab

Released:
DOI: 10.2210/pdb3j8w/pdb
PDB entry 3j8w coloured by chain, front view.
PDB entry 3j8w coloured by chain, side view.
PDB entry 3j8w coloured by chain, top view.
Source organisms:
Primary publication:
Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization.
Guan J, Bywaters SM, Brendle SA, Lee H, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S
Virology 483 253-63 (2015)
PMID: 25996608
Related structures: EMD-6184

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 780-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208879 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H263.A2 light chain Chains: J, K, L, M
Molecule details ›
Chains: J, K, L, M
Length: 109 amino acids
Theoretical weight: 11.94 KDa
Source organism: Mus musculus
H263.A2 heavy chain Chains: F, G, H, I
Molecule details ›
Chains: F, G, H, I
Length: 118 amino acids
Theoretical weight: 13.11 KDa
Source organism: Mus musculus
Major capsid protein L1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 455 amino acids
Theoretical weight: 50.87 KDa
Source organism: Human papillomavirus 16
UniProt:
  • Canonical: P03101 (Residues: 21-474; Coverage: 90%)
Gene name: L1
Sequence domains: L1 (late) protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 13Å
Relevant EMDB volumes: EMD-6184

Quick links

Citations

4 review citations

Self-assembling protein nanoparticles in the design of vaccines.
López-Sagaseta et al. (2016)
3 more

1 mention without citation

Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization.
Guan et al. (2015)