› 3h6g

X-ray diffraction
2.7Å resolution

Crystal structure of the GluR6 amino terminal domain dimer assembly

Released:
DOI: 10.2210/pdb3h6g/pdb
PDB entry 3h6g coloured by chain, front view.
PDB entry 3h6g coloured by chain, side view.
PDB entry 3h6g coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The N-terminal domain of GluR6-subtype glutamate receptor ion channels.
Kumar J, Schuck P, Jin R, Mayer ML
Nat Struct Mol Biol 16 631-8 (2009)
PMID: 19465914

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 395 amino acids
Theoretical weight: 44.75 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P42260 (Residues: 32-420; Coverage: 44%)
Gene names: Glur6, Grik2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand NAG 8 x NAG
Ligand TLA 2 x TLA
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P61
Unit cell:
a: 172.074Å b: 172.074Å c: 111.547Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.204 0.227
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
17 more

12 mentions without citation

Control of assembly and function of glutamate receptors by the amino-terminal domain.
Hansen et al. (2010)
11 more