› 3gc0

X-ray diffraction
2Å resolution

Structure of the CMGC CDK Kinase from Giardia lamblia in complex with AMP

Released:
DOI: 10.2210/pdb3gc0/pdb
PDB entry 3gc0 coloured by chain, front view.
PDB entry 3gc0 coloured by chain, side view.
PDB entry 3gc0 coloured by chain, top view.
Source organism: Giardia lamblia ATCC 50803
Primary publication:
Structure of a cyclin-dependent kinase from Giardia lamblia.
Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W
Acta Crystallogr Sect F Struct Biol Cryst Commun 67 1084-9 (2011)
PMID: 21904054

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 37.58 KDa
Source organism: Giardia lamblia ATCC 50803
Expression system: Escherichia coli
UniProt:
  • Canonical: A8BZ95 (Residues: 1-308; Coverage: 100%)
Gene names: GL50803_008037, GL50803_8037
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AMP 1 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 53.24Å b: 73.18Å c: 75.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.265
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Treatment of giardiasis: current status and future directions.
Watkins et al. (2014)

2 mentions without citation

The Seattle Structural Genomics Center for Infectious Disease (SSGCID).
Myler et al. (2009)
1 more