› 3ga3

X-ray diffraction
1.45Å resolution

Crystal structure of the C-terminal domain of human MDA5

Released:
DOI: 10.2210/pdb3ga3/pdb
PDB entry 3ga3 coloured by chain, front view.
PDB entry 3ga3 coloured by chain, side view.
PDB entry 3ga3 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Li P

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189847 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced helicase C domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BYX4 (Residues: 893-1017; Coverage: 12%)
Gene names: IFIH1, MDA5, RH116
Sequence domains: C-terminal domain of RIG-I
Structure domains: RIG-I-like receptor, C-terminal regulatory domain

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 28.41Å b: 60.92Å c: 36.443Å
α: 90° β: 102.58° γ: 90°
R-values:
R R work R free
0.18 0.18 0.204
Expression system: Escherichia coli

Quick links