› 3e7z

X-ray diffraction
1.7Å resolution

Structure of human insulin

Released:
DOI: 10.2210/pdb3e7z/pdb
PDB entry 3e7z coloured by chain, front view.
PDB entry 3e7z coloured by chain, side view.
PDB entry 3e7z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Timofeev VI, Lyashenko AV, Kislitsyn YA, Baidus AN, Kuranova IP

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
hetero hexamer
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-134182 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 29 amino acids
Theoretical weight: 3.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01308 (Residues: 25-53; Coverage: 34%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: R3
Unit cell:
a: 82.741Å b: 82.741Å c: 34.06Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.196 0.271
Expression system: Escherichia coli

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