› 3du5

X-ray diffraction
3.25Å resolution

Structure of the catalytic subunit of telomerase, TERT

Released:
DOI: 10.2210/pdb3du5/pdb
PDB entry 3du5 coloured by chain, front view.
PDB entry 3du5 coloured by chain, side view.
PDB entry 3du5 coloured by chain, top view.
Source organism: Tribolium castaneum
Primary publication:
Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Gillis AJ, Schuller AP, Skordalakes E
Nature 455 633-7 (2008)
PMID: 18758444

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomerase reverse transcriptase Chains: A, B
Molecule details ›
Chains: A, B
Length: 596 amino acids
Theoretical weight: 70.59 KDa
Source organism: Tribolium castaneum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0QHL8 (Residues: 1-596; Coverage: 100%)
Gene names: AUGUSTUS-3.0.2_10963, TERT, TcasGA2_TC010963
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P61
Unit cell:
a: 199.968Å b: 199.968Å c: 96.413Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.243 0.297
Expression system: Escherichia coli

Quick links

Citations

53 review citations

Telomeres and telomerase: three decades of progress.
Shay et al. (2019)
52 more

11 mentions without citation

Unraveling secrets of telomeres: one molecule at a time.
Lin et al. (2014)
10 more