› 3cuv

X-ray diffraction
1.93Å resolution

Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides

Released:
DOI: 10.2210/pdb3cuv/pdb
PDB entry 3cuv coloured by chain, front view.
PDB entry 3cuv coloured by chain, side view.
PDB entry 3cuv coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Entry authors: Kyritsi C, Chrysina ED, Leonidas DD, Zographos SE, Oikonomakos NG

Function and Biology Details

Reaction catalysed: 
((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen phosphorylase, muscle form Chain: A
Molecule details ›
Chain: A
Length: 842 amino acids
Theoretical weight: 97.52 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P00489 (Residues: 2-843; Coverage: 100%)
Gene name: PYGM
Sequence domains: Carbohydrate phosphorylase
Structure domains: Glycogen Phosphorylase B;

Ligands and Environments

2 bound ligands:
Ligand 475 1 x 475
Ligand DMS 15 x DMS
1 modified residue:
Ligand LLP 1 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P43212
Unit cell:
a: 126.45Å b: 126.45Å c: 115.465Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.231

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