› 3con

X-ray diffraction
1.65Å resolution

Crystal structure of the human NRAS GTPase bound with GDP

Released:
DOI: 10.2210/pdb3con/pdb
PDB entry 3con coloured by chain, front view.
PDB entry 3con coloured by chain, side view.
PDB entry 3con coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nedyalkova L, Tong Y, Tempel W, Shen L, Loppnau P, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133953 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase NRas Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01111 (Residues: 1-172; Coverage: 91%)
Gene names: HRAS1, NRAS
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand MG 4 x MG
Ligand GDP 1 x GDP
Ligand UNX 8 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P63
Unit cell:
a: 83.061Å b: 83.061Å c: 38.907Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.185 0.219
Expression system: Escherichia coli

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