› 3cm9

X-ray solution scattering

Solution Structure of Human SIgA2

Released:
DOI: 10.2210/pdb3cm9/pdb
PDB entry 3cm9 coloured by chain, ensemble of 10 models, front view.
PDB entry 3cm9 coloured by chain, ensemble of 10 models, side view.
PDB entry 3cm9 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses.
Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ
J Biol Chem 284 5077-87 (2009)
PMID: 19109255

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208532 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Immunoglobulin heavy chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 462 amino acids
Theoretical weight: 49.92 KDa
Source organism: Homo sapiens
Secretory component Chain: J
Molecule details ›
Chain: J
Length: 106 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 353-458; Coverage: 14%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain
Immunoglobulin light chain Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 214 amino acids
Theoretical weight: 23.22 KDa
Source organism: Homo sapiens
Secretory component Chain: S
Molecule details ›
Chain: S
Length: 585 amino acids
Theoretical weight: 64.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 19-603; Coverage: 78%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Quick links

Citations

8 review citations

Regional specialization within the intestinal immune system.
Mowat et al. (2014)
7 more

3 mentions without citation

The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses.
Bonner et al. (2009)
2 more