› 3ckl

X-ray diffraction
2Å resolution

Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol

Released:
DOI: 10.2210/pdb3ckl/pdb
PDB entry 3ckl coloured by chain, front view.
PDB entry 3ckl coloured by chain, side view.
PDB entry 3ckl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pan PW, Tempel W, Dong A, Loppnau P, Kozieradzki I, Edwards AM, Arrowsmith CH, Weigelt J, Bountra C, Bochkarev A, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129064 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase 1B1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 35.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43704 (Residues: 1-296; Coverage: 100%)
Gene names: ST1B2, SULT1B1, SULT1B2
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand STL 2 x STL
Ligand A3P 2 x A3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 78.819Å b: 47.613Å c: 92.666Å
α: 90° β: 93.95° γ: 90°
R-values:
R R work R free
0.184 0.181 0.241
Expression system: Escherichia coli

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