› 3cjw

X-ray diffraction
1.48Å resolution

Crystal structure of the human COUP-TFII ligand binding domain

Released:
DOI: 10.2210/pdb3cjw/pdb
PDB entry 3cjw coloured by chain, front view.
PDB entry 3cjw coloured by chain, side view.
PDB entry 3cjw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.
Kruse SW, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, Vonrhein C, Xu Y, Wang L, Tsai SY, Tsai MJ, Xu HE
PLoS Biol 6 e227 (2008)
PMID: 18798693

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-150232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COUP transcription factor 2 Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 27.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24468 (Residues: 175-414; Coverage: 58%)
Gene names: ARP1, NR2F2, TFCOUP2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: C2
Unit cell:
a: 97.854Å b: 47.762Å c: 43.128Å
α: 90° β: 100.87° γ: 90°
R-values:
R R work R free
0.168 0.168 0.238
Expression system: Escherichia coli

Quick links

Citations

57 review citations

Transcriptional control of endothelial cell development.
De Val et al. (2009)
56 more

15 mentions without citation

Pathophysiological Heterogeneity of the BBSOA Neurodevelopmental Syndrome.
Bertacchi et al. (2022)
14 more