› 3chl

X-ray diffraction
1.9Å resolution

Crystal Structure of Alpha-14 Giardin with magnesium bound

Released:
DOI: 10.2210/pdb3chl/pdb
PDB entry 3chl coloured by chain, front view.
PDB entry 3chl coloured by chain, side view.
PDB entry 3chl coloured by chain, top view.
Source organism: Giardia intestinalis
Primary publication:
Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia.
Pathuri P, Nguyen ET, Ozorowski G, Svärd SG, Luecke H
J Mol Biol 385 1098-112 (2009)
PMID: 19046974

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192422 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin E1 Chain: A
Molecule details ›
Chain: A
Length: 337 amino acids
Theoretical weight: 38.64 KDa
Source organism: Giardia intestinalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NFS4 (Residues: 1-337; Coverage: 100%)
Gene names: ANX21, ANXE1
Sequence domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: R3
Unit cell:
a: 133.859Å b: 133.859Å c: 69.668Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.231
Expression system: Escherichia coli

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Citations

1 review citation

Parasite annexins--new molecules with potential for drug and vaccine development.
Hofmann et al. (2010)
7 other articles