› 3c4e

X-ray diffraction
1.98Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 273 amino acids
Theoretical weight: 31.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 33-305; Coverage: 87%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IMD 4 x IMD
Ligand C4E 4 x C4E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P65
Unit cell:
a: 197.455Å b: 197.455Å c: 80.679Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.214 0.245
Expression system: Escherichia coli

Quick links

Citations

267 review citations

New driver mutations in non-small-cell lung cancer.
Pao et al. (2011)
266 more

15 mentions without citation

The azaindole framework in the design of kinase inhibitors.
Mérour et al. (2014)
14 more