› 3bi4

X-ray diffraction
2.2Å resolution

Crystal structures of fms1 in complex with its inhibitors

Released:
DOI: 10.2210/pdb3bi4/pdb
PDB entry 3bi4 coloured by chain, front view.
PDB entry 3bi4 coloured by chain, side view.
PDB entry 3bi4 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Entry authors: Huang Q, Hao Q

Function and Biology Details

Reaction catalysed: 
N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyamine oxidase FMS1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 516 amino acids
Theoretical weight: 58.94 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P50264 (Residues: 1-508; Coverage: 100%)
Gene names: FMS1, YM9711.09, YMR020W
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
1 bound ligand:
Ligand 298 2 x 298
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 161.589Å b: 102.852Å c: 76.647Å
α: 90° β: 94.37° γ: 90°
R-values:
R R work R free
0.227 0.227 0.265
Expression system: Escherichia coli BL21(DE3)

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