3av5

X-ray diffraction
3.25Å resolution

Crystal structure of mouse DNA methyltransferase 1 with AdoHcy

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-146802 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA (cytosine-5)-methyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 1330 amino acids
Theoretical weight: 150.8 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P13864 (Residues: 291-1620; Coverage: 82%)
Gene names: Dnmt, Dnmt1, Met1, Uim
Sequence domains:

Ligands and Environments


Cofactor: Ligand SAH 1 x SAH
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21212
Unit cell:
a: 134.993Å b: 96.92Å c: 130.615Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.184 0.264
Expression system: Spodoptera frugiperda