› 3a8q

X-ray diffraction
3.2Å resolution

Low-resolution crystal structure of the Tiam2 PHCCEx domain

Released:
DOI: 10.2210/pdb3a8q/pdb
PDB entry 3a8q coloured by chain, front view.
PDB entry 3a8q coloured by chain, side view.
PDB entry 3a8q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.
Terawaki S, Kitano K, Mori T, Zhai Y, Higuchi Y, Itoh N, Watanabe T, Kaibuchi K, Hakoshima T
EMBO J 29 236-50 (2010)
PMID: 19893486

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180596 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor TIAM2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 263 amino acids
Theoretical weight: 29.93 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZPF3 (Residues: 500-757; Coverage: 15%)
Gene names: Kiaa2016, Stef, Tiam2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P43212
Unit cell:
a: 105.56Å b: 105.56Å c: 287.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.283 0.283 0.332
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.
Cook et al. (2014)
4 more