› 2z5o

X-ray diffraction
3.2Å resolution

Complex of Transportin 1 with JKTBP NLS

Released:
DOI: 10.2210/pdb2z5o/pdb
PDB entry 2z5o coloured by chain, front view.
PDB entry 2z5o coloured by chain, side view.
PDB entry 2z5o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for substrate recognition and dissociation by human transportin 1.
Imasaki T, Shimizu T, Hashimoto H, Hidaka Y, Kose S, Imamoto N, Yamada M, Sato M
Mol Cell 28 57-67 (2007)
PMID: 17936704

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187824 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transportin-1 Chain: A
Molecule details ›
Chain: A
Length: 890 amino acids
Theoretical weight: 101.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 9-898; Coverage: 99%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Heterogeneous nuclear ribonucleoprotein D-like Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 869 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21212
Unit cell:
a: 132.306Å b: 169.805Å c: 68.458Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.279
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

9 review citations

Nuclear import by karyopherin-βs: recognition and inhibition.
Chook et al. (2011)
8 more

2 mentions without citation

Transportin-1: A Nuclear Import Receptor with Moonlighting Functions.
Mboukou et al. (2021)
1 more