› 2pfi

X-ray diffraction
1.6Å resolution

Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka

Released:
DOI: 10.2210/pdb2pfi/pdb
PDB entry 2pfi coloured by chain, front view.
PDB entry 2pfi coloured by chain, side view.
PDB entry 2pfi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface.
Markovic S, Dutzler R
Structure 15 715-25 (2007)
PMID: 17562318

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein ClC-Ka Chains: A, B
Molecule details ›
Chains: A, B
Length: 164 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51800 (Residues: 533-687; Coverage: 23%)
Gene name: CLCNKA
Sequence domains: CBS domain
Structure domains: CBS-domain

Ligands and Environments

2 bound ligands:
Ligand IOD 1 x IOD
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 35.283Å b: 83.421Å c: 59.888Å
α: 90° β: 92.48° γ: 90°
R-values:
R R work R free
0.2 0.2 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Jentsch TJ. (2008)
17 more

9 mentions without citation

Contrast Agents Delivery: An Up-to-Date Review of Nanodiagnostics in Neuroimaging.
Teleanu et al. (2019)
8 more