› 2ox8

X-ray diffraction
2.5Å resolution

Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.

Released:
DOI: 10.2210/pdb2ox8/pdb
PDB entry 2ox8 coloured by chain, front view.
PDB entry 2ox8 coloured by chain, side view.
PDB entry 2ox8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism.
Feinberg H, Taylor ME, Weis WI
J Biol Chem 282 17250-8 (2007)
PMID: 17420244

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collectin-12 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 140 amino acids
Theoretical weight: 16.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5KU26 (Residues: 603-742; Coverage: 19%)
Gene names: CLP1, COLEC12, NSR2, SCARA4, SRCL
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

3 bound ligands:
Ligand ZN 16 x ZN
Ligand CL 12 x CL
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P32
Unit cell:
a: 80.422Å b: 80.422Å c: 67.159Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.233 0.308
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Scavenger receptors in homeostasis and immunity.
Canton et al. (2013)
5 more

7 mentions without citation

Evolution of the arginase fold and functional diversity.
Dowling et al. (2008)
6 more