› 2id2

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate + NADP(+) + H(2)O = 3-phospho-D-glycerate + NADPH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 475 amino acids
Theoretical weight: 51.26 KDa
Source organism: Streptococcus mutans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q59931 (Residues: 1-475; Coverage: 100%)
Gene names: SMU_676, gapN
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21212
Unit cell:
a: 143.7Å b: 154.4Å c: 115Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.176 0.227
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Kinetic and structural features of betaine aldehyde dehydrogenases: mechanistic and regulatory implications.
Muñoz-Clares et al. (2010)
7 other articles

3 mentions without citation

Invariant Thr244 is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans.
Pailot et al. (2006)
2 more