› 2zvt

X-ray diffraction
1.9Å resolution

Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2

Released:
DOI: 10.2210/pdb2zvt/pdb
PDB entry 2zvt coloured by chain, front view.
PDB entry 2zvt coloured by chain, side view.
PDB entry 2zvt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands.
Waku T, Shiraki T, Oyama T, Morikawa K
FEBS Lett 583 320-4 (2009)
PMID: 19101554

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 223-504; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand PTG 2 x PTG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: C2
Unit cell:
a: 92.982Å b: 61.392Å c: 118.539Å
α: 90° β: 102.89° γ: 90°
R-values:
R R work R free
0.251 0.251 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.
Hoxha M. (2018)
3 more

2 mentions without citation

Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.
Riu et al. (2011)
1 more