› 2zjx

X-ray diffraction
1.09Å resolution

Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond

Released:
DOI: 10.2210/pdb2zjx/pdb
PDB entry 2zjx coloured by chain, front view.
PDB entry 2zjx coloured by chain, side view.
PDB entry 2zjx coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines.
Islam MM, Sohya S, Noguchi K, Yohda M, Kuroda Y
Proc Natl Acad Sci U S A 105 15334-9 (2008)
PMID: 18829434

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pancreatic trypsin inhibitor Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.37 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00974 (Residues: 36-93; Coverage: 73%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21
Unit cell:
a: 25.065Å b: 40.792Å c: 54.879Å
α: 90° β: 100.93° γ: 90°
R-values:
R R work R free
0.183 not available 0.209
Expression system: Escherichia coli

Quick links

Citations

11 citation in other articles

Funneling and frustration in the energy landscapes of some designed and simplified proteins.
Truong et al. (2013)
10 more

5 mentions without citation

Recent Advances in Studying Toll-like Receptors with the Use of Computational Methods.
Bzówka et al. (2023)
4 more