› 2z7x

X-ray diffraction
2.1Å resolution

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Released:
DOI: 10.2210/pdb2z7x/pdb
PDB entry 2z7x coloured by chain, front view.
PDB entry 2z7x coloured by chain, side view.
PDB entry 2z7x coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO
Cell 130 1071-82 (2007)
PMID: 17889651

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130044 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (7 distinct):
Toll-like receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 549 amino acids
Theoretical weight: 62.24 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60603 (Residues: 27-539, 540-544, 545-553; Coverage: 69%)
Gene names: TIL4, TLR2
Sequence domains:
Structure domains: Ribonuclease Inhibitor
Toll-like receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 520 amino acids
Theoretical weight: 59.37 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15399 (Residues: 25-476, 478-495, 496-501, 502-539; Coverage: 67%)
Gene names: KIAA0012, TLR1
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor
Pam3CSK4 Chain: C
Molecule details ›
Chain: C
Length: 6 amino acids
Theoretical weight: 725 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, NDG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand PLM 1 x PLM
Ligand Z41 1 x Z41
1 modified residue:
Ligand DCY 1 x DCY

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P21212
Unit cell:
a: 200.303Å b: 120.14Å c: 74.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.244 0.27
Expression systems:
  • Trichoplusia ni
  • Not provided

Quick links

Citations

271 review citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Kawai et al. (2010)
270 more

121 mentions without citation

The structural biology of Toll-like receptors.
Botos et al. (2011)
120 more