› 2z5y

X-ray diffraction
2.17Å resolution

Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine

Released:
DOI: 10.2210/pdb2z5y/pdb
PDB entry 2z5y coloured by chain, front view.
PDB entry 2z5y coloured by chain, side view.
PDB entry 2z5y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors.
Son SY, Ma J, Kondou Y, Yoshimura M, Yamashita E, Tsukihara T
Proc Natl Acad Sci U S A 105 5739-44 (2008)
PMID: 18391214

Function and Biology Details

Reactions catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-149227 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amine oxidase [flavin-containing] A Chain: A
Molecule details ›
Chain: A
Length: 513 amino acids
Theoretical weight: 58.27 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P21397 (Residues: 12-524; Coverage: 97%)
Gene name: MAOA
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
2 bound ligands:
Ligand HRM 1 x HRM
Ligand DCX 2 x DCX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C222
Unit cell:
a: 135.547Å b: 217.364Å c: 54.804Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.244
Expression system: Saccharomyces cerevisiae

Quick links

Citations

35 review citations

Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases.
Edmondson et al. (2009)
34 more

29 mentions without citation

Helix insertion into bilayers and the evolution of membrane proteins.
Renthal R. (2010)
28 more