› 2yzd

X-ray diffraction
2.24Å resolution

Crystal structure of uricase from Arthrobacter globiformis in complex with 8-azaxanthin (inhibitor)

Released:
DOI: 10.2210/pdb2yzd/pdb
PDB entry 2yzd coloured by chain, front view.
PDB entry 2yzd coloured by chain, side view.
PDB entry 2yzd coloured by chain, top view.
Source organism: Arthrobacter globiformis
Entry authors: Juan ECM, Hossain MT, Hoque MM, Suzuki K, Sekiguchi T, Takenaka A

Function and Biology Details

Reaction catalysed: 
Urate + O(2) + H(2)O = 5-hydroxyisourate + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uricase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 302 amino acids
Theoretical weight: 33.9 KDa
Source organism: Arthrobacter globiformis
UniProt:
  • Canonical: D0VWQ1 (Residues: 1-302; Coverage: 100%)
Gene name: uox
Sequence domains: Uricase
Structure domains: Urate Oxidase;

Ligands and Environments

1 bound ligand:
Ligand AZA 8 x AZA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 83.33Å b: 122.28Å c: 283.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.239

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