› 2yfy

X-ray diffraction
3.1Å resolution

SERCA in the HnE2 State Complexed With Debutanoyl Thapsigargin

Released:
DOI: 10.2210/pdb2yfy/pdb
PDB entry 2yfy coloured by chain, front view.
PDB entry 2yfy coloured by chain, side view.
PDB entry 2yfy coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes.
Sonntag Y, Musgaard M, Olesen C, Schiøtt B, Møller JV, Nissen P, Thøgersen L
Nat Commun 2 304 (2011)
PMID: 21556058

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

3 bound ligands:
Ligand 9TN 1 x 9TN
Ligand K 1 x K
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 71.36Å b: 71.36Å c: 587.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.239 0.278

Quick links

Citations

12 review citations

Influences of membrane mimetic environments on membrane protein structures.
Zhou et al. (2013)
11 more

1 mention without citation

Novel and recurrent variants of ATP2C1 identified in patients with Hailey-Hailey disease.
Sawicka et al. (2020)