› 2xus

X-ray diffraction
1.91Å resolution

Crystal Structure of the BRMS1 N-terminal region

Released:
DOI: 10.2210/pdb2xus/pdb
PDB entry 2xus coloured by chain, front view.
PDB entry 2xus coloured by chain, side view.
PDB entry 2xus coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of BRMS1 nuclear export signal and SNX6 interacting region reveals a hexamer formed by antiparallel coiled coils.
Spínola-Amilibia M, Rivera J, Ortiz-Lombardía M, Romero A, Neira JL, Bravo J
J Mol Biol 411 1114-27 (2011)
PMID: 21777593

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
homo hexamer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Breast cancer metastasis-suppressor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 49 amino acids
Theoretical weight: 6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HCU9 (Residues: 51-98; Coverage: 20%)
Gene name: BRMS1
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: R32
Unit cell:
a: 60.399Å b: 60.399Å c: 133.485Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.2 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.
Kodura et al. (2015)
9 other articles

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)