› 2wp7

X-ray diffraction
1.9Å resolution

Crystal structure of deSUMOylase(DUF862)

Released:
DOI: 10.2210/pdb2wp7/pdb
PDB entry 2wp7 coloured by chain, front view.
PDB entry 2wp7 coloured by chain, side view.
PDB entry 2wp7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily.
Suh HY, Kim JH, Woo JS, Ku B, Shin EJ, Yun Y, Oh BH
Proteins 80 2099-104 (2012)
PMID: 22498933

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190004 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Desumoylating isopeptidase 1 Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 18.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9CQT7 (Residues: 1-168; Coverage: 100%)
Gene names: D15Wsu75e, Desi1, Fam152b, Pppde2
Sequence domains: PPPDE putative peptidase domain
Structure domains: PPPDE domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P43212
Unit cell:
a: 42.033Å b: 42.033Å c: 164.514Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Sumoylation: a regulatory protein modification in health and disease.
Flotho et al. (2013)
13 more

3 mentions without citation

Function and regulation of SUMO proteases.
Hickey et al. (2012)
2 more