› 2w60

X-ray diffraction
1.5Å resolution

Anti citrullinated Collagen type 2 antibody acc4

Released:
DOI: 10.2210/pdb2w60/pdb
PDB entry 2w60 coloured by chain, front view.
PDB entry 2w60 coloured by chain, side view.
PDB entry 2w60 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R
J Exp Med 206 449-62 (2009)
PMID: 19204106

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213186 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4 Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 23.42 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4 Chain: B
Molecule details ›
Chain: B
Length: 217 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P212121
Unit cell:
a: 44.8Å b: 70Å c: 136.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.22

Quick links

Citations

56 review citations

Rheumatoid arthritis.
Scott et al. (2010)
55 more

3 mentions without citation

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
Uysal et al. (2009)
2 more