› 2vaf

X-ray diffraction
3.8Å resolution

Crystal structure of Human Cardiac Calsequestrin

Released:
DOI: 10.2210/pdb2vaf/pdb
PDB entry 2vaf coloured by chain, front view.
PDB entry 2vaf coloured by chain, side view.
PDB entry 2vaf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of human cardiac calsequestrin and its deleterious mutants.
Kim E, Youn B, Kemper L, Campbell C, Milting H, Varsanyi M, Kang C
J Mol Biol 373 1047-57 (2007)
PMID: 17881003

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calsequestrin-2 Chain: A
Molecule details ›
Chain: A
Length: 378 amino acids
Theoretical weight: 44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14958 (Residues: 22-399; Coverage: 100%)
Gene name: CASQ2
Sequence domains: Calsequestrin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I4122
Unit cell:
a: 150.65Å b: 150.65Å c: 227.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.274 0.274 0.325
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis.
Priori et al. (2011)
18 more

8 mentions without citation

Redox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases.
Nikolaienko et al. (2018)
7 more