› 2u2f

Solution NMR

SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN OF HU2AF65

Released:
DOI: 10.2210/pdb2u2f/pdb
PDB entry 2u2f coloured by chain, front view.
PDB entry 2u2f coloured by chain, side view.
PDB entry 2u2f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).
Ito T, Muto Y, Green MR, Yokoyama S
EMBO J 18 4523-34 (1999)
PMID: 10449418

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Splicing factor U2AF 65 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26368 (Residues: 258-342; Coverage: 18%)
Gene names: U2AF2, U2AF65
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structure and function of the Pre-mRNA splicing machine.
Sperling et al. (2008)
3 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more