› 2tbd

Solution NMR

SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb2tbd/pdb
PDB entry 2tbd coloured by chain, ensemble of 30 models, front view.
PDB entry 2tbd coloured by chain, ensemble of 30 models, side view.
PDB entry 2tbd coloured by chain, ensemble of 30 models, top view.
Source organism: Macaca mulatta polyomavirus 1
Primary publication:
Solution structure of the origin DNA-binding domain of SV40 T-antigen.
Luo X, Sanford DG, Bullock PA, Bachovchin WW
Nat Struct Biol 3 1034-9 (1996)
PMID: 8946857

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Large T antigen Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.41 KDa
Source organism: Macaca mulatta polyomavirus 1
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q98ZP7 (Residues: 131-260; Coverage: 24%)
Sequence domains: Origin of replication binding protein
Structure domains: Replication Protein E1; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

The initiation of simian virus 40 DNA replication in vitro.
Bullock PA. (1997)
11 more

4 mentions without citation

The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.
Ou et al. (2011)
3 more