2rt5

Solution NMR

Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-188763 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Msx2-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 18.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96T58 (Residues: 3496-3664; Coverage: 5%)
Gene names: KIAA0929, MINT, SHARP, SPEN
Sequence domains: SPOC domain
Structure domains: Ku70; Chain: A; Domain 2
Nuclear receptor corepressor 2 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y618 (Residues: 2507-2514; Coverage: 0%)
Gene names: CTG26, NCOR2

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided