› 2rq4

Solution NMR

Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1

Released:
DOI: 10.2210/pdb2rq4/pdb
PDB entry 2rq4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2rq4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2rq4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3.
Tsuda K, Kuwasako K, Takahashi M, Someya T, Inoue M, Terada T, Kobayashi N, Shirouzu M, Kigawa T, Tanaka A, Sugano S, Güntert P, Muto Y, Yokoyama S
Nucleic Acids Res 37 5151-66 (2009)
PMID: 19553194

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CUGBP Elav-like family member 1 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: E. coli-cell-free synthesis
UniProt:
  • Canonical: Q92879 (Residues: 383-484; Coverage: 21%)
Gene names: BRUNOL2, CELF1, CUGBP, CUGBP1, NAB50
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: E. coli-cell-free synthesis

Quick links

Citations

14 review citations

The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.
Dasgupta et al. (2012)
13 more

4 mentions without citation

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3.
Tsuda et al. (2009)
3 more