› 2r88

X-ray diffraction
2.6Å resolution

Crystal structure of the long-chain fatty acid transporter FadL mutant delta S3 kink

Released:
DOI: 10.2210/pdb2r88/pdb
PDB entry 2r88 coloured by chain, front view.
PDB entry 2r88 coloured by chain, side view.
PDB entry 2r88 coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Transmembrane passage of hydrophobic compounds through a protein channel wall.
Hearn EM, Patel DR, Lepore BW, Indic M, van den Berg B
Nature 458 367-70 (2009)
PMID: 19182779

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145291 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Long-chain fatty acid transport protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 426 amino acids
Theoretical weight: 46.63 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P10384 (Residues: 26-446; Coverage: 100%)
Gene names: JW2341, b2344, fadL, ttr
Sequence domains: Outer membrane protein transport protein (OMPP1/FadL/TodX)
Structure domains: Outer membrane protein transport protein (OMPP1/FadL/TodX)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: C2221
Unit cell:
a: 91.327Å b: 91.37Å c: 267.317Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.262 0.262 0.294
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation.
Kamaly et al. (2012)
14 more

3 mentions without citation

The structural biology of β-barrel membrane proteins: a summary of recent reports.
Fairman et al. (2011)
2 more