› 2r4v

X-ray diffraction
1.85Å resolution

Structure of human CLIC2, crystal form A

Released:
DOI: 10.2210/pdb2r4v/pdb
PDB entry 2r4v coloured by chain, front view.
PDB entry 2r4v coloured by chain, side view.
PDB entry 2r4v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Janus protein human CLIC2.
Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Littler DR, Brown LJ, Mazzanti M, Breit SN, Curmi PM, Dulhunty AF, Board PG, Parker MW
J Mol Biol 374 719-31 (2007)
PMID: 17945253

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride intracellular channel protein 2 Chain: A
Molecule details ›
Chain: A
Length: 247 amino acids
Theoretical weight: 28.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15247 (Residues: 1-247; Coverage: 100%)
Gene name: CLIC2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GSH 2 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: P212121
Unit cell:
a: 44.015Å b: 74.722Å c: 79.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.25
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Glutathione transferases, regulators of cellular metabolism and physiology.
Board et al. (2013)
15 more

6 mentions without citation

The still mysterious roles of cysteine-containing glutathione transferases in plants.
Lallement et al. (2014)
5 more