› 2qz8

X-ray diffraction
2.16Å resolution

Crystal structure of Mycobacterium tuberculosis Leucine response regulatory protein (LrpA)

Released:
DOI: 10.2210/pdb2qz8/pdb
PDB entry 2qz8 coloured by chain, front view.
PDB entry 2qz8 coloured by chain, side view.
PDB entry 2qz8 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.
Reddy MC, Gokulan K, Jacobs WR, Ioerger TR, Sacchettini JC
Protein Sci 17 159-70 (2008)
PMID: 18042675

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH asnC-type domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 149 amino acids
Theoretical weight: 16.45 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P96896 (Residues: 5-150; Coverage: 97%)
Gene names: MT3390, lrp
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: C2221
Unit cell:
a: 146.284Å b: 149.9Å c: 62.506Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.255
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors.
Deng et al. (2011)
2 more

1 mention without citation

Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.
Reddy et al. (2008)