› 2qoc

X-ray diffraction
1.25Å resolution

Human EphA3 kinase domain, phosphorylated, AMP-PNP bound structure

Released:
DOI: 10.2210/pdb2qoc/pdb
PDB entry 2qoc coloured by chain, front view.
PDB entry 2qoc coloured by chain, side view.
PDB entry 2qoc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).
Davis TL, Walker JR, Loppnau P, Butler-Cole C, Allali-Hassani A, Dhe-Paganon S
Structure 16 873-84 (2008)
PMID: 18547520

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 38.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 606-947; Coverage: 36%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand BME 1 x BME
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 53.79Å b: 38.337Å c: 76.439Å
α: 90° β: 102.07° γ: 90°
R-values:
R R work R free
0.17 0.169 0.186
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Structure and function of VEGF receptors.
Stuttfeld et al. (2009)
12 more

5 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
4 more