› 2qkq

X-ray diffraction
2.1Å resolution

Structure of the SAM Domain of Human Ephrin Type-B Receptor 4

Released:
DOI: 10.2210/pdb2qkq/pdb
PDB entry 2qkq coloured by chain, front view.
PDB entry 2qkq coloured by chain, side view.
PDB entry 2qkq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Cuerrier D, Butler-Cole C, Weigelt J, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-B receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 83 amino acids
Theoretical weight: 9.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54760 (Residues: 896-977; Coverage: 8%)
Gene names: EPHB4, HTK, MYK1, TYRO11
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P42
Unit cell:
a: 73.566Å b: 73.566Å c: 25.679Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.244
Expression system: Escherichia coli BL21(DE3)

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