› 2qh5

X-ray diffraction
2.3Å resolution

Crystal structure of mannose-6-phosphate isomerase from Helicobacter pylori

Released:
DOI: 10.2210/pdb2qh5/pdb
PDB entry 2qh5 coloured by chain, front view.
PDB entry 2qh5 coloured by chain, side view.
PDB entry 2qh5 coloured by chain, top view.
Source organism: Helicobacter pylori 26695
Entry authors: Patskovsky Y, Ramagopal U, Toro R, Sauder JM, Dickey M, Iizuka M, Maletic M, Wasserman SR, Koss J, Burley SK, Almo SC, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127687 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mannose-1-phosphate guanylyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 35 KDa
Source organism: Helicobacter pylori 26695
Expression system: Escherichia coli
UniProt:
  • Canonical: O24884 (Residues: 2-298; Coverage: 63%)
Gene name: HP_0043
Sequence domains: Nucleotidyl transferase
Structure domains: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 57.829Å b: 66.415Å c: 163.959Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.234 0.289
Expression system: Escherichia coli

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