Function and Biology Details
Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase VI, subunit A
- Spo11/DNA topoisomerase VI subunit A
- DNA topoisomerase VI, subunit B
- DNA topoisomerase VI, subunit B, transducer
- Histidine kinase/HSP90-like ATPase
- Histidine kinase/HSP90-like ATPase superfamily
- DNA topoisomerase VI, subunit B, C-terminal
- Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
6 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Type 2 DNA topoisomerase 6 (preferred)
PDBe Complex ID:
PDB-CPX-185804 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.3.1
Spacegroup:
P6422
Expression system: Escherichia coli