› 2pwo

X-ray diffraction
1.45Å resolution

Crystal Structure of HIV-1 CA146 A92E Psuedo Cell

Released:
DOI: 10.2210/pdb2pwo/pdb
PDB entry 2pwo coloured by chain, front view.
PDB entry 2pwo coloured by chain, side view.
PDB entry 2pwo coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein.
Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP
J Mol Biol 373 355-66 (2007)
PMID: 17826792

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retroviral nucleocapsid Gag protein p24 C-terminal domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 146 amino acids
Theoretical weight: 16.26 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A9PKC6 (Residues: 33-178; Coverage: 53%)
Gene name: gag
Sequence domains: gag protein p24 N-terminal domain
Structure domains: Human Immunodeficiency Virus Type 1 Capsid Protein

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P1
Unit cell:
a: 46.225Å b: 48.208Å c: 58.928Å
α: 83.01° β: 71.28° γ: 87.43°
R-values:
R R work R free
0.173 0.17 0.216
Expression system: Escherichia coli BL21

Quick links

Citations

27 review citations

HIV-1 assembly, release and maturation.
Freed EO. (2015)
26 more

2 mentions without citation

Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein.
Kelly et al. (2007)
1 more