› 2psw

X-ray diffraction
2.1Å resolution

Human MAK3 homolog in complex with CoA

Released:
DOI: 10.2210/pdb2psw/pdb
PDB entry 2psw coloured by chain, front view.
PDB entry 2psw coloured by chain, side view.
PDB entry 2psw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Schuetz A, Antoshenko T, Wu H, Bernstein G, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + an N-terminal-L-methionyl-L-alanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-alpha-acetyltransferase 50 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 170 amino acids
Theoretical weight: 19.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9GZZ1 (Residues: 2-169; Coverage: 99%)
Gene names: MAK3, NAA50, NAT13, NAT5
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand COA 3 x COA
No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 47.643Å b: 102.913Å c: 67.157Å
α: 90° β: 105.81° γ: 90°
R-values:
R R work R free
0.201 0.197 0.265
Expression system: Escherichia coli BL21(DE3)

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