› 2poy

X-ray diffraction
1.8Å resolution

Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A

Released:
DOI: 10.2210/pdb2poy/pdb
PDB entry 2poy coloured by chain, front view.
PDB entry 2poy coloured by chain, side view.
PDB entry 2poy coloured by chain, top view.
Source organisms:
Entry authors: Wernimont AK, Lew J, Hills T, Kozieradzki I, Lin YH, Hassanali A, Zhao Y, Schapira M, Arrowsmith CH, Edwards AM, Weigelt J, Sundstrom M, Bochkarev A, Hui R, Artz JD, Xiao T, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107147 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 186 amino acids
Theoretical weight: 20.33 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: A3FQA7 (Residues: 3-170; Coverage: 98%)
Gene name: cgd2_4120
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN A Chains: T, U, V
Molecule details ›
Chains: T, U, V
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 3 x DAL
Ligand MLE 12 x MLE
Ligand MVA 3 x MVA
Ligand BMT 3 x BMT
Ligand ABA 3 x ABA
Ligand SAR 3 x SAR

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 36.482Å b: 119.303Å c: 127.877Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.233
Expression systems:
  • Escherichia coli
  • Not provided

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