› 2p7a

X-ray diffraction
2.3Å resolution

Crystal Structure of Estrogen Related Receptor g in complex with 3-methyl phenol

Released:
DOI: 10.2210/pdb2p7a/pdb
PDB entry 2p7a coloured by chain, front view.
PDB entry 2p7a coloured by chain, side view.
PDB entry 2p7a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds.
Abad MC, Askari H, O'Neill J, Klinger AL, Milligan C, Lewandowski F, Springer B, Spurlino J, Rentzeperis D
J Steroid Biochem Mol Biol 108 44-54 (2008)
PMID: 17964775

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158633 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 251 amino acids
Theoretical weight: 28.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 43M 1 x 43M
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 64.279Å b: 64.279Å c: 137.178Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.256
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A.
Hengstler et al. (2011)
6 more

2 mentions without citation

A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus.
Gu et al. (2013)
1 more