› 2p6x

X-ray diffraction
1.9Å resolution

Crystal structure of human tyrosine phosphatase PTPN22

Released:
DOI: 10.2210/pdb2p6x/pdb
PDB entry 2p6x coloured by chain, front view.
PDB entry 2p6x coloured by chain, side view.
PDB entry 2p6x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 22 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 36.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2R2 (Residues: 1-302; Coverage: 37%)
Gene names: PTPN22, PTPN8
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 60.961Å b: 48.442Å c: 119.805Å
α: 90° β: 102.84° γ: 90°
R-values:
R R work R free
0.166 0.164 0.217
Expression system: Escherichia coli

Quick links

Citations

58 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
57 more

18 mentions without citation

Protein tyrosine phosphatases: structure, function, and implication in human disease.
Tautz et al. (2013)
17 more