› 2ogd

X-ray diffraction
2Å resolution

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527

Released:
DOI: 10.2210/pdb2ogd/pdb
PDB entry 2ogd coloured by chain, front view.
PDB entry 2ogd coloured by chain, side view.
PDB entry 2ogd coloured by chain, top view.
Source organism: Trypanosoma brucei
Entry authors: Cao R, Gao Y, Robinson H, Goddard A, Oldfield E

Function and Biology Details

Reaction catalysed: 
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 390 amino acids
Theoretical weight: 44.48 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86C09 (Residues: 1-367; Coverage: 100%)
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

5 bound ligands:
Ligand ACT 4 x ACT
Ligand MG 6 x MG
Ligand SUF 2 x SUF
Ligand BME 3 x BME
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: C2
Unit cell:
a: 134.613Å b: 118.37Å c: 62.758Å
α: 90° β: 112.16° γ: 90°
R-values:
R R work R free
0.193 0.193 0.229
Expression system: Escherichia coli

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